Connectomics in Schizophrenia : identifying the underlying cause of the disease

2 Likes

I havent found a lot on the subject of connectomics and schizophrenia but it is my belief that this is how scientists will find the architectural cause of sz. It is about identifying the faulty wiring.

http://www.eng.unimelb.edu.au/research/projects/mapping-the-human-schizophrenia-connectome-320

2 Likes

This is where optogenetics could help. One day they will possibly rewire it to right circuit:

  1. https://www.ncbi.nlm.nih.gov/pubmed/21482453

  2. https://www.osa-opn.org/home/newsroom/2015/april/optogenetics_shines_a_light_on_schizophrenia/

2 Likes

We shouldn’t leave out cognitive training and brain “exercise” which has been shown to have an effect not only functionally, but physically, using fMRI.

The brain forms connections when you learn and practice things, the changes caused can be positive or negative (maladaptive.)

2 Likes

Hey there @twinklestars .
Isn’t it true that the brain of very young people like kids and teens has considerably more plasticity than the brain of adults?
In other words the older the person gets the less the level of plasticity?

You may be referring to a recent study that found few new cells growing in adult brains. This conflicts with some other studies that do find new cells - so I don’t think we can say for certain without more studies.

But even without growing new brain cells, you can make connections between existing ones. That appears to be the case at any age.

You don’t actually learn things by growing new brain cells, so…

1 Like

I should show the same tenacity that I show in physical training in the realm of cognitive training.

2 Likes

Yes, brain plasticity decreases with age.

I side with @twinklestars, I believe people of all ages should dream big.

2 Likes

@anon9798425 and I don’t actually disagree, plasticity does decrease with age, but that doesn’t mean there is none when you’re an adult.

It’s harder to teach an old dog new tricks, but it’s not impossible.

2 Likes

@twinklestars I will tell you more, we should believe the level of plasticity at advanced
age is AWESOME since this will motivate us to engage in new activities and learn new things.
If we believe what @anon9798425 says that the level of plasticity decreases with age,
this belief is counterproductive motivation wise for an adult.

Brain plasticity decreases with age, but brain plasticity isn’t everything. Intelligence increases well into adulthood, and the applied parts of it, like knowledge, increase well into old age. Old people are generally wiser, more knowlegdeable, more capable of feeling love, more secure in themselves, and happier (as long as they are relatively healthy). I’m very optimistic about growing old. I expect I will still be intelligent and very capable of learning and contributing to society, but just much more content with myself and at ease with the world.

4 Likes