Cognitive insight in first-episode schizophrenia: Further evidence for a role of the ventrolateral prefrontal cortex

I found this really interesting. It seems that researchers are identifying the part of the brain that deals with self-reflection, and that this part of the brain could be damaged / or not working properly with schizophrenia. But this study is only correlation (and everyone will tell you that correlation is not the same as causation). So the research continues…


In people with psychoses, Self-Reflectiveness may rely on the right ventrolateral prefrontal cortex (VLPFC). We used functional magnetic resonance imaging (fMRI) and a novel virtual reality paradigm to evaluate the role of the VLPFC for Self-Reflectiveness in 25 first-episode of schizophrenia (FES) participants

Self-Reflectiveness, measured with the Beck Cognitive Insight Scale, was significantly and positively correlated to activation in bilateral VLPFC in FES, but not in controls, providing further evidence that the VLPFC supports Self-Reflectiveness in FES.


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