Cognitive control deficit in patients with first-episode schizophrenia is associated with complex deviations of early brain development

This study seems to suggest that the cognitive control challenges in schizophrenia are a result of early brain development issues. More and more research is showing that many of early schizophrenia risk factors seem to be a result of early brain developmental disruptions, from flu during pregnancy, to nutritional deficiencies during pregnancy and early childhood (not enough choline, B vitamins, etc.) and stress during pregnancy and early childhood.


To our knowledge, our study provides the first evidence of cumulative and interactive effects of different neurodevelopmental markers on cognitive control efficiency in patients with schizophrenia. Such findings, in line with the neurodevelopmental model of schizophrenia, support the notion that cognitive control impairments in patients with schizophrenia may be the final common pathway of several early neurodevelopmental mechanisms.



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