Whats the next step from here? Im on 300mg clozapine and it doesnt work. I still hear voices and have delusions and negatives. My memory is terrible. I hate it
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Highest dose is 900.
Up the dose.
I’m also on 300, and have some symptoms
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I am at 450mg a day and have no voices. It does not help with negatives. 
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How long have you been on 300mg?
The first step is to ensure that a patient has received an adequate dose of clozapine, as reflected by a plasma concentration of at least 1,070 nM/L, for 8 to 12 weeks (2). If the patient is a rapid clozapine metabolizer (due to genetic makeup or because he or she is a heavy smoker), we augment the clozapine with 25 mg to 50 mg of fluvoxamine since it can inhibit cytochrome 1A2 and slow down drug metabolism. Although this strategy can complicate treatment, the hospital setting allows us to closely monitor the patient.
If it were me, I’d make sure my plasma concentration of clozapine was good. This is a blood test your psychiatrist can do (they may already be doing it)
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