Schizophrenia.com

Cell transplants may be a novel treatment for schizophrenia

Rodent research suggests feasibility of restoring neuron function

SAN ANTONIO — Research from the School of Medicine at The University of Texas Health Science Center at San Antonio suggests the exciting possibility of using cell transplants to treat schizophrenia.

Cells called “interneurons” inhibit activity within brain regions, but this braking or governing function is impaired in schizophrenia. Consequently, a group of nerve cells called the dopamine system go into overdrive. Different branches of the dopamine system are involved in cognition, movement and emotions.

“Since these cells are not functioning properly, our idea is to replace them,” said study senior author Daniel Lodge, Ph.D., assistant professor of pharmacology in the School of Medicine.

Transplant restored normal function

Dr. Lodge and lead author Stephanie Perez, graduate student in his laboratory, biopsied tissue from rat fetuses, isolated cells from the tissue and injected the cells into a brain center called the hippocampus. This center regulates the dopamine system and plays a role in learning, memory and executive functions such as decision making. Rats treated with the transplanted cells have restored hippocampal and dopamine function.

Stem cells are able to become different types of cells, and in this case interneurons were selected. “We put in a lot of cells and not all survived, but a significant portion did and restored hippocampal and dopamine function back to normal,” Dr. Lodge said.

‘You can essentially fix the problem’

Unlike traditional approaches to treating schizophrenia, such as medications and deep-brain stimulation, transplantation of interneurons potentially can produce a permanent solution. “You can essentially fix the problem,” Dr. Lodge said. “Ultimately, if this is translated to humans, we want to reprogram a patient’s own cells and use them.”

After meeting with other students, Perez brought the research idea to Dr. Lodge. “The students have journal club, and somebody had done a similar experiment to restore motor deficits and had good results,” Perez said. “We thought, why can’t we use it for schizophrenia and have good results, and so far we have.”

The study is in Molecular Psychiatry.

This work was supported by a mental health research grant from the Hogg Foundation and an R01 grant (MH090067) and F31 grant (MH098564) from the National Institutes of Health. Representative images were generated in the Core Optical Imaging Facility, which is supported by The University of Texas Health Science Center at San Antonio, NIH-NCI P30 CA54174 (The Cancer Therapy & Research Center at The University of Texas Health Science Center at San Antonio) and NIH-NIA P01AG19316.

Hippocampal interneuron transplants reverse aberrant dopamine system function and behavior in a rodent model of schizophrenia
SM Perez and DJ Lodge
Molecular Psychiatry (2013), 1-6
Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, 7703 Floyd Curl Drive, MC 7764, San Antonio, TX 78229, USA.

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This looks like it might be a permanent solution, but then again the risks might outweigh the benefits.

That’s just amazing!
100 years from now it might be available for people.

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By the time this treatment approves, there will be better meds. And the only rich schizos. Will be able to have surgery. Most of them will still stick on meds, most of us are poor.

when will this be tried in humans?

and why would it take 100 years?

This sounds amazing if it works.

Things are moving fast in the Stem Cell area - lots of progress, so the 100 year estimate by Scarlett is very negative.

Here is some recent news as an example:

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Stem cells are amazing I believe they will end up being the cure. I Just wish there was a bigger push in this direction rather then investing in new drugs.

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New Stem Cell development:

New Stem Cell Breakthrough Represents An Evolution In Modern Medicine

http://www.thealmagest.com/new-stem-cell-breakthrough-represents-evolution-modern-medicine/9791

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Those scientists are going to try on humans organs in 3 years. So far it worked on mice. Hopefully, after treating hart,liver,kidney and etc. they will movie on to the brain. I must start saving some money.

how do you know they will be trying in 3 years?

I saw it on NHK channel, its an Asian news channel in english. They said in 3 yrs. they will start clinical trial on humans, but most likely on the hart. Hopefully if it works on the organs they might consider using the same treatment on the brain.

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I am sorry I was so negative…In regards to this issue I am bitter, don’t trust the pharamceutical companies and feel somewhat hopeless as my daughter is effected. Still it does not do to bring the rest of the world down to my low levels and I am sure that things have improved since my initial experiences when my Mum was being ‘treated’ in the 60-80s.
This link talks about genes and the multiple origins of SZ

Certainly seems to be exciting stuff.