Carbonyl stress suggests strategy for treatment-resistant schizophrenia

Patients with schizophrenia who have enhanced carbonyl stress have clinical features associated with treatment resistance, say researchers.

Mitsuhiro Miyashita (Tokyo Metropolitan Institute of Medical Science, Japan) and team used two biomarkers to identify patients with carbonyl stress: high plasma pentosidine (>62.9 ng/ml) and low pyridoxal levels (<6 ng/ml in men, <4 ng/ml in women). Pyridoxal was representative of vitamin B6 (pyridoxamine).

Noting that current medications with the most success in treatment-resistant schizophrenia also carry the most severe adverse effects, the researchers say their findings “support the idea that simple treatments that reduce carbonyl stress, such as supplementation of pyridoxamine, may be of novel therapeutic benefit for this subset of patients.”

Full Article:
https://www.medwirenews.com/mental-health/psychotic-disorders/carbonyl-stress-suggests-strategy-for-treatment-resistant-schizophrenia/117292

Related Papers:

https://onlinelibrary.wiley.com/doi/10.1111/pcn.12216

Imteresting post, ill read the article and comment later. Although i dont have treatment resistant schizophrenia

Anyone read the article?

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