Carbonyl stress suggests strategy for treatment-resistant schizophrenia

Patients with schizophrenia who have enhanced carbonyl stress have clinical features associated with treatment resistance, say researchers.

Mitsuhiro Miyashita (Tokyo Metropolitan Institute of Medical Science, Japan) and team used two biomarkers to identify patients with carbonyl stress: high plasma pentosidine (>62.9 ng/ml) and low pyridoxal levels (<6 ng/ml in men, <4 ng/ml in women). Pyridoxal was representative of vitamin B6 (pyridoxamine).

Noting that current medications with the most success in treatment-resistant schizophrenia also carry the most severe adverse effects, the researchers say their findings “support the idea that simple treatments that reduce carbonyl stress, such as supplementation of pyridoxamine, may be of novel therapeutic benefit for this subset of patients.”

Full Article:

Related Papers:

Imteresting post, ill read the article and comment later. Although i dont have treatment resistant schizophrenia

Anyone read the article?

Typically, we like to leave inactive threads alone and just start a new thread instead. This is different than how some forums are run, but we do it this way because it frequently upsets users to have old topics revived when they are no longer relevant. It can also be frustrating to the person who revived the thread when they don’t get a reply, because the original poster is no longer active or no longer finds the topic relevant. Feel free to start a new thread on this topic.

1 Like