https://physicsworld.com/a/big-data-framework-seeks-treatment-targets-for-alzheimers-disease/
AI is going to be the big game changer including for sz.
Identification and validation
Repeating the same approach for other pathways related to neurodegenerative diseases revealed that of all the top-scoring genes tested, only NDUFA9 was common to all pathways. This gene is part of a Complex I subunit in the mitochondria and plays a big part in mitochondrial respiration and synthesis of adenosine triphosphate (ATP).
To confirm the role of NDUFA9 in AD, the team carried out experiments on an animal model. A transgenic worm line was engineered to develop AD-like pathologies in its muscle cells at a specific stage in its life cycle. This leads to observable paralysis of the worms. By feeding the worms with bacteria that delivered an interfering RNA (RNAi), the researchers were able to inhibit the expression of NDUFA9.