Like all of the anti-P’s, Anipryl selegeline (usually used for pts with Parkinson’s, but because it is an MAO inhibitor and has off-label, anti-depressive effects for some sz pts, a very small # of sz pts are now on it for their negative symptoms, though the jury is still out on this), and Risperdal risperidone are each molecules of a particular sort coming into contact with a brain full of other molecules of a particular sort. Thus, they will work just dandy for some, fairly well for some, not so great for some, and plain horrible for the rest.
While research into who this is so is underway on a broad front, the complexities involved suggest that it may be a long, long time before p-docs are able to give sz patients a “test” of some sort that determines (relatively) precisely what particular anti-P is best for their particular brain full of molecules.
If sufficiently intrigued, look into Stephen Stahl’s work, as he does a nice verbal and pictorial job of explaining all this.
cc: @everhopeful @turningthepage @Svvs @dana @mmasters