Best medication that works? you

From experience what is the latest news of best medication that works for you?

Now, I’m taking 20 mg Selegiline every morning, Risperidone 4 mg every morning and 4 mg every night

and I’m so happy… I finally found out that Olanzapine 20 mg is the worst choice and Risperidone 8 mg in two divided doses along with 20 mg Selegiline is the best combination.

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Still abilify at 25 mg for me and klonopin at 1.0 mg

Glad your med combo is working for you :smile:

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Abilify for me so far too.

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right now i’m on 60 mg of geodon and i haven’t had any problems with it so far. much better than zyprexa, i had so many terrible side effects on that stuff…

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Like all of the anti-P’s, Anipryl selegeline (usually used for pts with Parkinson’s, but because it is an MAO inhibitor and has off-label, anti-depressive effects for some sz pts, a very small # of sz pts are now on it for their negative symptoms, though the jury is still out on this), and Risperdal risperidone are each molecules of a particular sort coming into contact with a brain full of other molecules of a particular sort. Thus, they will work just dandy for some, fairly well for some, not so great for some, and plain horrible for the rest.

While research into who this is so is underway on a broad front, the complexities involved suggest that it may be a long, long time before p-docs are able to give sz patients a “test” of some sort that determines (relatively) precisely what particular anti-P is best for their particular brain full of molecules.

If sufficiently intrigued, look into Stephen Stahl’s work, as he does a nice verbal and pictorial job of explaining all this.

cc: @everhopeful @turningthepage @Svvs @dana @mmasters

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Tried a handful, Zyprexa 7.5mg and haldol 5mg for me. Although I think a better drug will come along one day. I’m waiting for iti007

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For me it’s been risperadal 6 mg and latuda 40 mg

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That’s always a possibility. Zyprexa olanzepine and (especially) Haldol haloperidone are getting pretty long in the tooth now, and there are a good dozen newer anti-Ps out there you and your p-doc can look into.

If you’re new here on the forum, keep and eye peeled to see all the meds discussed here and how they work for people. You may find that there are meds out there you haven’t tried yet that may be very helpful. That said, meds are very rarely to complete answer, and…

Piles of research show that sz pts tend to get “better” when they…

  1. Get a copy of this book and read it and have their families read it, as well.

  2. Get properly diagnosed by a board-certified psychopharmacologist who specializes in the psychotic disorders. One can find them at…

  3. Work with that “psychiatrist” (or “p-doc”) to develop a medication formula that stabilizes their symptoms sufficiently so that they can tackle the psychotherapy that will disentangle their thinking.

  4. The best of the therapies for that currently include…
    DBT –
    MBSR –
    ACT –
    10 StEP –

  5. the even newer somatic psychotherapies like…
    MBBT –
    SEPT –
    SMPT –

  6. or standard CBTs, like…
    REBT –
    Schematherapy –
    Learned Optimism –
    Standard CBT –


waiting and hoping 4 iti 007

I’m happily on prolixin (generic fluphenazine) and have no side effects whatsoever. I was on risperdal but it had sexual side effects and made me not want to live. I tried abilify and I found that I was just delusional enough on it that I made some horrible financial decisions on it. long story.

hey notmoses aren’t u hopeful on meds…
for some these therapy works for some it doesn’t…
so what u r thought on future coming anti-ps

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Good on you for having luck with prolixin. It caused me a series of sideaffects but was effective. Meanwhile abilify causes me no side effects. Just proves we all operate differently. Seems almost everyone gets sexual sideaffects on risperdal though.

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I know most people hate it, but Zyprexa is a really good med for me. Few side-effects, works well and helps me get closer to a normal and healthy weight (I am on 10 mg and it has helped but I need to gain a little more weight). Seroquel does not work so well for me, I am on 600 mg. Will probably ask my pdoc to reduce my Seroquel when I am more stable. She said no last time.

The therapies are important. Expecting a med to fix your mental illness on its own is like expecting a lottery ticket to fix your financial issues. It might for one in a million people, but the rest have to work towards it.



Haldol 10mg and klonopin 2mg work best for me. The haldol at this low of a dose doesn’t really give me many side effects and it works the best of any AP I’ve tried.

Clozapine is the only AP that ever did anything for me and it has relatively minor side-effects, I was a non-responder to the other drugs.

Seroquel for me, but it has to be a super high dose.

I’m on 80 mg X 2 Geodon and 400 X 2 Seroquel. That’s about right for me. I’m also on Wellbutrin, and I am thinking about asking my pdoc to increase my dose of that.

Very much agreed, of course. The Big Problem – and this is true for virtually all psych patients whose anxiety or depression symptoms are reduced to a level of tolerability – is that once the “pain” is gone, so is the motivation to determine, dis-cover, root out and dismantle the psychodynamic, cognitive and behavioral (read “life style”) causes of the pain. Too often, this is because the patient thinks (according to what he hears from others or just unconsciously believes) that psychotherapy will make the pain worse again.

Oh, well.

cc: @mmasters @anon93437440 @dmdar @turningthepage @Treebeard @jukebox @far_cry0 @everhopeful @LED

Therapy works well for about 90% of those who 1) are medicinally stablized enough to be able to do it, and 2) are sufficiently motivated to do it (see my other comment above about motivation and pain). The percentage of efficacy drops into the 70s for those who aren’t motivated, and into the 20s or 30s for those who aren’t stabilized with meds.

Unless or until some way other than dopamine (“Da”) receptor site blockage is found – or if the pharmacologists are able to come up with even “narrower” Da receptor targeting (not easy) – my med-school-trained supposition is that any “better approach” is well off into the future.

Da-channel-blocking anti-Ps (like, say, Clozaril) do not treat the causes of sz (which are just plain legion; see the latest edition of the book at the link below). They only treat the symptoms of over-active, Da-connected, neuron chains in the limbic system. Which means they will block connections one needs for “normal” function, as well as the ones that cause sz.