Antipsychotics and risk of natural death in patients with schizophrenia - PMC

Medications
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Antipsychotics and risk of natural death in patients with schizophrenia - PMC.

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Some people have been claiming that AP polypharmacy is “dangerous”. I wasn’t sure so I found this.

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In this population-based nested case–control study involving 601 patients with schizophrenia, we found the risk of mortality decreased significantly for antipsychotics use, especially antipsychotic monotherapy; and antipsychotics polypharmacy did not contribute to the excess mortality.

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I find this study a bit hard to swallow to be honest. I could see decreased mortality overall due to less suicide or drug use or whatever…saying it decreases your natural mortality rate seems off to me. Everybody knows about the side effects of antipsychotics. Increased risk of diabetes, weight gain and so on…so I’m not sure what to make of it. Antipsychotics being good for your physical health is a bit hard to swallow.

Dont get me wrong, I think they are necessary in a lot of cases, I’m just not grasping the benefits to physical health…

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As far as I am concerned, this whole so called study is a farce. And I’m on polypharmacy.

I’m just going to keep my risk to a minimum by maintaining my weight and exercise, eating nutritiously, and moderating my alcohol intake.

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Medication is necesary, but lots of times subject is overmedicated in the long run. It is called being preventive.

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To represent both sides of the debate, I asked Bing AI:

“what is the increased chance of sudden death syndrome from taking antipsychotics?”

It answered:

"According to a meta-analysis of observational studies published in Clinical Pharmacology and Therapeutics, some antipsychotics increase the risk of sudden death1. Six antipsychotics significantly increased the risk of sudden cardiac death (SCD) or sudden unexpected death (SED): clozapine, haloperidol, olanzapine, quetiapine, risperidone and thioridazine1. The variation in risk of SCD/SED between antipsychotics is not related to a class effect (typical vs. atypical antipsychotics), but it seems related to potency of antipsychotics to block hERG channels, which is particularly high for risperidone, haloperidol and thioridazine1.

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You should be asking about all cause mortality

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Thanks for summing it up. My doctor told me the same thing. People live longer on antipsychotics. Strangely when i don’t take my medicine my physical health seems to fall apart.

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To me i feel like it does. For some reason the last times i was off my medicine, i could hardly walk better than a 90 year old. I felt so weighed down and weak. And everytime i would eat my heart would get ectopic beats for hours. Those are two big reasons im afraid to quit my medicine. Im afraid my physical and heart health will deteriorate.

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i m more reliable on aps.i don t think its going to make problem on me on long term.i m very happy with my medicines

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I can only talk on my own behalf. But.polypharmacology with the two meds I’m on now has has prevented me from attempting suicide or dying of alcohol intoxication.

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I know my meds have prevented suicide with me for over 30 years now.

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That’s great Skinny. I too had suicide thoughts before meds

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That’s wonderful @columbus. I hope you have long term success with your meds as well.

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I’ve tried to fumble around with my meds some times lately but I finally realize that I have to stay on my dose of meds.

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