An experimental medicine study of the phosphodiesterase-4 inhibitor, roflumilast, on working memory-related brain activity and episodic memory in schizophrenia patients

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Interesting. Boehringer has a PDE9 inhibitor they are working on for schizophrenia, offhand I don’t know of other PDE4 drugs.

Intracellular (of ITI-007/lumateperone fame) apparently working on a PDE inhibitor.
http://www.intracellulartherapies.com/products-and-technology/pde-inhibitor-platform/