Amisulpride equally effective as clozapine for positive symptoms

Medications
1

Get pdf of the study here: [1] Its good for people who wish to avoid weight gain and blood tests

Comparative efficacy and tolerability of 32 oral antipsychotics for the acute treatment of adults with multi-episode schizophrenia: a systematic review and network meta-analysis

[1] https://www.thelancet.com/article/S0140-6736(19)31135-3/fulltext

1 Like
2

What is amulsipride? Is it a antipsychotic?

3

I thought Clozapine was ranked 1st with Ami 2nd.

Have been stable on Amisulpride for over two years now.

Shame it’s not available in North America.

No weight gain, in fact weight loss…

4

Man at one point I was on 800mg clozapine + 1200mg amisulpride lol

1 Like
5

Yes its an antipsychotic. But its not available in usa or canada

6

This many times posted study says Clozapine is the most effective…
Can you cite where you read that Clozapine isn’t 1st?

“all antipsychotics reduced overall symptoms more than placebo (although not statistically significant for six drugs), with standardised mean differences ranging from −0·89 (95% CrI −1·08 to −0·71) for clozapine to −0·03 (−0·59 to 0·52) for levomepromazine (40 815 participants).”

7

Every source on the internet says Clozapine is 1st.

8

89% of participants improved with Clozapine.

9

I am on 525mg of clozaril, works great for me, i have been on it about ten years now, side effectsare hard at times but the pros outweigh the cons!

10

On page 4, Amisulpride is 0.69 while clozapine is 0.64

558×749 103 KB

1 Like
11

I would be very wary of placing too much value on Amisulpride’s ‘superior’ performance.

12

What was their P value? was it greater than 0.05? (It implies correlation/effectivness)

13

Weird, overall symptoms Clozapine is #1. All other studies show that Clozapine is #1.

14

Thats true for overall symptoms. But i think maybe clozapine and amisulpride is equal in reducing positive symptoms.

15

Oh I see why Clozapine isn’t first. N=626 for Amisulpride while N=31 for Clozapine. Results for Clozapine aren’t as accurate as Amisulpride.

16

N is the number of patients taking it.

17

Which strongly points to this result being an outlier , until there are further results pointing in the same direction,

1 Like
18

Amisulpride has kept me relatively stable for seven years now

I was on clozapine for eight months in 2004 and it made me into zombie. I don’t think I was on it long enough to see its good effects. But I got it stopped because of unbearable side effects

1 Like