ANother study showing that its really hard to avoid high rates of weight gain on Olanzapine, no matter what the support.
Long-term weight gain was high in both groups, with no statistically significant differences between the standard or intense behavioral weight interventions in BMI or weight. Safety, tolerability, and effectiveness findings were generally consistent with the known profile of olanzapine in adolescents.
HC Detke, MP DelBello, J Landry, VP Hoffmann, A Heinloth and RW Dittmann,
Journal of child and adolescent psychopharmacology, Dec 2016
To evaluate the 52-week safety/tolerability of oral olanzapine for adolescents with schizophrenia or bipolar mania and compare effectiveness of a standard versus intense behavioral weight intervention in mitigating risk of weight gain.Patients 13-17 years old with schizophrenia (Brief Psychiatric Rating Scale for Children [BPRS-C] total score >30; item score ≥3 for hallucinations, delusions, or peculiar fantasies) or bipolar I disorder (manic or mixed episode; Young Mania Rating Scale [YMRS] total score ≥15) received open-label olanzapine (2.5-20 mg/day) and were randomized to standard (n = 102; a single weight counseling session) or intense (n = 101; weight counseling at each study visit) weight intervention. The primary outcome measure was mean change in body mass index (BMI) from baseline to 52 weeks using mixed-model repeated measures. Symptomatology was also assessed.No statistically significant differences between groups were observed in mean baseline-to-52-week change in BMI (standard: +3.6 kg/m2; intense: +2.8 kg/m2; p = 0.150) or weight (standard: +12.1 kg; intense: +9.6 kg; p = 0.148). Percentage of patients at endpoint who had gained ≥15% of their baseline weight was 40% for the standard group and 31% for the intense group (p = 0.187). Safety/tolerability results were generally consistent with those of previous olanzapine studies in adolescents, with the most notable exception being the finding of a mean decrease in prolactin. On symptomatology measures, patients with schizophrenia had a mean baseline-to-52-week change in BPRS-C of -32.5 (standard deviation [SD] = 10.8), and patients with bipolar disorder had a mean change in YMRS of -16.7 (SD = 8.9), with clinically and statistically significant improvement starting at 3-4 days for each.Long-term weight gain was high in both groups, with no statistically significant differences between the standard or intense behavioral weight interventions in BMI or weight. Safety, tolerability, and effectiveness findings were generally consistent with the known profile of olanzapine in adolescents.
Every AP I’ve been on has made me gain weight.
Which one resulted in the least amount of weight gain for you?
I’ve tried Respiridone, Latuda (briefly), and Abilify…
I’ve found Abilify has the least amount of weight gain. Although I wasn’t on Latuda long enough to get a proper measure.
I take a bcomplex with abilify and that curbs abilify induced hunger pangs. I’ve also been seeing a dietician for the last year, and I lost 20kg=44 pounds .
This is the bcomplex I use
Start taking the bcomplex and see what happens.
A word of caution though, I take a bcomplex with just 100% rda of vitamins. I’ve found that high powered bcomplexes (like 1000% rda) interact with abilify in a bad way.
I got 14 kilo on paliperidone.i m trying to give some weight.
I gained 15 kg just on 5mg Olanazapine…!!!
Clozapine made me put on a lot of weight.
I lost weight on 12.5mg Olanzapine eating low-ish carb - it’s possible. If I eat whatever I want, I definitely gain weight quickly.
Tell me about it, i take zyprexa.
Tried many diets, little effect.
Gym, 3 days a week, still 40 pounds overweight.
Still, when I see a gp, I’m told ‘you’ve let yourself go,’ or asked ‘do you eat many pies?’
Makes me angry, the ignorant fools.
If i ‘let myself go’ or ‘ate pies’ then I would be 100 pounds heavier than i am.