Multiple drugs hit this receptor and none of them are good for negative symptoms. Copy paste from Wikipedia:
Atypical antipsychotic drugs like clozapine, olanzapine, quetiapine, risperidone and asenapine are relatively potent antagonists of 5-HT2A as are some of the lower potency old generation/typical antipsychotics. Other antagonists are MDL-100,907 (prototype of another new series of 5-HT2A antagonists) and cyproheptadine.
Dozens of drugs are serotonin 2a antagonists, yet such drugs are not remarkably helpful in negative symptoms. I am certain min-101 will not work as no one understands how negative symptoms work, but clearly 5ht2a antagonism which has been done for decades doesn't do much.
Pimavanserin is another drug which inhibits only 5ht2a. Low doses of lumateperone primarily inhibit this receptor, yet they haven't reported a remarkable improvement in negative symptoms for this drug. They are using a mechanism which has already failed.