What's going on with nicotine-like drugs?

Just wondering if anyone can fill me in on what happened to meds that work similarly to nicotine… Did they ever go to clinical trials?

One of them, Encenicline (EVP-6124), is in ungoing phase III clinical trials.
http://www.ukmi.nhs.uk/applications/ndo/record_view_open.asp?newDrugID=5590

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