My son was on Zyprexa for 2 years until recently and he experienced no positive symptoms on it but he gained 160 pounds during those 2 years. He also had low motivation. Due to increasing physical issues due to weight gain, he switched to Vraylar 6 weeks ago and titrated off of Zyprexa.
His negative symptoms disappeared while on Vraylar. He loves it and could concentrate and had motivation. He also was not hungry all the time like when he was on Zypreza. So he was also losing weight. We were so hopeful.
Well, after two years of no delusions, they have come back and he has been hospitalized for 4 days now. He is back on Zyprexa and waiting to become stable again.
I am not sure why Vraylar works for some people and not others.