This is an update from my earlier post in relation to my spouse.
Sarcosine was tried for approx 8 week and we met with failure. It triggered a psychotic break with hypomania symptoms, Hubby was/is on a carb rich/low protein diet without medications as prescribed by his MD in an effort to reduce weight gain caused by years of meds. He responded well to diet,but, when the sarcosine was added in the effects were minimal and increasing to the recommended dosage levels as in the study he went off the rails. The sarcosine was titered down to 1g with same effects and still no improvement. It is believed that he has what is called Serine Excess which is known to cause psychotic episodes when on the above mentioned diet with sarcosine/d-serine supplements. He will be tested for this in the coming days.
L-Lysine was met with similar failure after he withdrew the sarcosine. However, he will revisit the L-Lysine once he has stablised again. We are not ready to give up on this supplement as of yet.
NAC- Was discont. and later re-introduced within the last week when it was discovered that NAC can be altered during the 1st psychosis. Currently and based on the blood work, he is on appox 600 mgsx3 daily. Lowering polyunsaturated fats in foods will be key to the success or failure of NAC with him.
Pellagra-Vitamin B-3 def. Hubby was discovered to have pellagra co-morbid with def in Vitamins B1, B-2,B-6 and B-12. He is currently taking 3000 mgs daily of B-3 and if he goes down or off this supplement the results are noticeable. His doctor's have said that the B-3 therapy for him will be a life long commitment. The rest of the B's, he takes as directed in the mornings.
Gluten-We have begun removing gluten foods from the diet in an effort to see if this improves his symptoms. Because we live in the same household, I get to be gluten free too. Going gluten free will take some time as ALL gluten needs to be removed for this to have any noticed effect in his schizophrenia. And it will takes month as we cannot shock the system so to speak. It's amazing where this stuff hides too.
He will be tested for the MTHFR mutation, Histadelia, Wilson's Disease and Histapenia to rule out any medical causes.
L-Theanine-This seems to be our wonder drug for the moment as it calms the symptoms down and allows him to sleep through the night. He takes 1200 mgs 3x daily with meals.
Vitamin C-1500 mgs 3x daily with his B-3.
Fish oil-Krill(organic)-1000 mgs 3x daily
Alpha Lipoic Acid-We have just upped his dose a bit to scrub his receptors a little more.
He will begin CB therapy as soon as he is stable again. He had to take his meds that he had on stand by in case of emergency. And he wasn't happy about it because he was doing well for months without it. But, I know when he is getting "squirrely" and I can sweet talk him into doing so. He will remain on the Latuda for approx 2 weeks then titer down and off.
Goal still remains life without any meds whatsoever. He spent 20 years or so stable with meds so we are hopeful that he can have that without them.
I will keep you updated on the NAC.