Just saw this - perhaps of interest:
Sarcosine Shows Promise As a New Way to Relieve Depression
In a brief, six-week trial on depressed patients, sarcosine even outperformed the antidepressant citalopram (Celexa).
Sarcosine is a derivative of glycine, the smallest of the amino acids. It has previously shown to help patients with obsessive-compulsive disorder (OCD).
It may be that by simply changing the level of activity of the NMDA receptor sarcosine enhances neuroplasticity, the ability to remodel nerve networks in the brain.
It's been nearly three decades since the last truly new drugs to treat depression were developed. And while currently available antidepressants are the most common treatment for depression, they may increase the likelihood of depression recurring.
They also do not work for everyone, suggesting that drugs such as sarcosine, which affect different pathways, may have a role to play in helping ease the burden of depression.
and the paper abstract:
and the OCD paper: