With a €4 Million budget, the m-RESIST Project (Mobile Therapeutic Attention for Patients with Treatment Resistant Schizophrenia) aims to develop a therapeutic program that draws on the support of mobile devices and actively involves patients with treatment-resistant schizophrenia. This will make them capable of self-managing their illness, as well as support their carers.
Here is more information on best treatment plans for people with treatment-resistant schizophrenia:
Treatment-resistant Schizophrenia: Evidence-based Strategies
Treatment-resistant symptoms complicate the clinical course of schizophrenia, and a large proportion of patients do not reach functional recovery. In consequence, polypharmacy is frequently used in treatment-refractory cases, addressing psychotic positive, negative and cognitive symptoms, treatment-emergent side effects caused by antipsychotics and comorbid depressive or obsessive-compulsive symptoms. To a large extent, such strategies are not covered by pharmacological guidelines which strongly suggest antipsychotic monotherapy. Add-on strategies comprise combinations of several antipsychotic agents and augmentations with mood stabilizers; moreover, antidepressants and experimental substances are applied. Based on the accumulated evidence of clinical trials and meta-analyses, combinations of clozapine with certain second-generation antipsychotic agents and the augmentation of antipsychotics with antidepressants seem recommendable, while the augmentation with mood stabilizers cannot be considered superior to placebo. Forthcoming investigations will have to focus on innovative pharmacological agents, the clinical spectrum of cognitive deficits and the implementation of cognitive behavioral therapy.