Hi folks! I can't sleep

Andy · May 29, 2017, 8:42am

Hi all! I couldn’t sleep this morning. The voices have risen. I have a psychiatric appointment today, and I’ve scheduled an appointment with a psychologist.

How are you?

anon22646328 · May 29, 2017, 8:44am

I’m doing cool.

Andy · May 29, 2017, 8:48am

Is it really necessary to take Geodon with 500 calories?

Andy · May 29, 2017, 8:54am

@sirBoring

I’m taking Omega 3 and a multivitamin now. It’s important to drink a lot of water so the meds work better.

Read and listening to music help me also.

anon12381882 · May 29, 2017, 9:09am

You have an appointment today? It’s a holiday.

Andy · May 29, 2017, 9:13am

I live in Brazil.

far_cry0 · May 29, 2017, 9:30am

Sup andy…what are u upto…

Andy · May 31, 2017, 11:26am

@far_cry0

Hi! I’m thinking about changing to another psychiatrist.
I’m taking Omega 3 pills and a multivitamin and trying to eat 500 calories before taking Geodon.

Leaf · May 31, 2017, 11:38am

I messed up my sleep cycle again, so I’m up. I once took Geodon they didn’t tell me I had to eat with it???

Moonwalker · May 31, 2017, 1:42pm

I never ate with Geodon

Andy · May 31, 2017, 4:27pm

@tera

This seems to do more effect. Eating 500 calories before Geodon.
I’m earing less voices.

Andy · May 31, 2017, 7:42pm

@tera
@Moonwalker

ncbi.nlm.nih.gov

The impact of calories and fat content of meals on oral ziprasidone absorption: a randomized, open-label, crossover trial.

K Gandelman, JA Alderman, P Glue, I Lombardo, RR LaBadie, M Versavel and SH Preskorn, The Journal of clinical psychiatry, Jan 2009

Food is known to increase the bioavailability of ziprasidone. Therefore, we evaluated the effects of meals of differing caloric and fat content on steady-state ziprasidone exposure in a stable, treated group of subjects with DSM-IV diagnoses of schizophrenia, schizoaffective disorder, bipolar disorder, or psychotic disorder (not otherwise specified) who were already receiving oral ziprasidone as their standard therapy.Patients took ziprasidone under 6 meal conditions in randomized sequences (fasted, low calorie/low fat, low calorie/high fat, medium calorie/high fat, high calorie/low fat, and high calorie/high fat); each crossover period was separated by at least 3 days for washout of the previous meal condition. Serial blood samples were obtained over the 12 hours postdose. The study was conducted from July 27 to September 28 of 2006.Maximum ziprasidone exposures in this study were observed with high-calorie meals (1000 kcal), which were nearly twice those observed under fasting conditions. The medium-calorie meal (500 kcal) was associated with exposures similar to the high-calorie meals. Low-calorie meals (250 kcal) were associated with exposures that were approximately 60% to 90% lower than those of medium- and high-calorie meals, and approached exposures seen under fasting conditions. Fat content of the meal had no significant effect on ziprasidone absorption. The ziprasidone exposures observed with medium- and high-calorie meals had less variability than those with low-calorie meals and under fasting conditions.These results confirm that ziprasidone should be taken with food and that a meal equal to or greater than 500 kcal, irrespective of fat content, is required for optimal and reproducible bioavailability of the administered dose.

Leaf · June 1, 2017, 2:39pm

thanks, good to know

Andy · June 1, 2017, 6:06pm

ncbi.nlm.nih.gov

Using oral ziprasidone effectively: the food effect and dose-response.

L Citrome, Advances in therapy, Aug 2009

Ziprasidone is a newer "atypical" or "second-generation" antipsychotic. Oral ziprasidone (ziprasidone hydrochloride) has been approved by the US Food and Drug Administration (FDA) for the treatment of schizophrenia, and acute manic or mixed episodes associated with bipolar disorder (with or without psychotic features). Comparisons with other second-generation antipsychotics in meta-analyses reveal similar efficacy to that observed for quetiapine or aripiprazole, but inferior efficacy to that of olanzapine or risperidone in the treatment of schizophrenia. However, the rate of dose titration and the dose achieved may have an important bearing on ziprasidone's efficacy profile, with a target dose range of 120-160 mg/day being associated with optimal symptom control and greater persistence with treatment. In addition, enhancing ziprasidone's effectiveness requires ensuring that ziprasidone is administered with a 500 kcal meal; otherwise, absorption of oral ziprasidone is substantially reduced and cannot be compensated for by increasing the prescribed dose. Regarding tolerability, ziprasidone has important advantages in that it is not associated with clinically significant weight gain or adverse changes in cholesterol, triglycerides, or glycemic control, and patients may experience moderate improvement in these measures when switching to ziprasidone from a different antipsychotic. Ziprasidone also lacks significant persistent effects on prolactin levels, is not anticholinergic, and only infrequently causes extrapyramidal side effects or postural hypotension; however, it can be associated with somnolence. Ziprasidone may prolong the electrocardiogram (ECG) QT interval but this does not appear to pose a substantial clinical problem. Provided that an adequate dose of ziprasidone is prescribed, and administered with a 500 kcal meal, ziprasidone can be effectively used to control symptoms without the long-term liabilities of metabolic side effects.

Anonaccount · June 3, 2017, 5:40am

It’s now 12:30 am and I’m still up. I stayed up until 4:30 am this morning and slept in until past noon. I want to sleep now. I am a bit sleepy but I have been drinking caffeinated coffee all day so, I’m afraid that is going to keep me up.