Elevated levels of Insulin-like Growth Factor-1 (IGF-1) in drug-naïve patients with psychosis

anon79999497 · October 21, 2016, 3:36pm

ncbi.nlm.nih.gov

Elevated levels of Insulin-like Growth Factor-1 (IGF-1) in drug-naïve patients with psychosis.

P Petrikis, VA Boumba, AT Tzallas, PV Voulgari, DT Archimandriti, P Skapinakis and V Mavreas, Psychiatry research, Dec 30 2016

Insulin-like growth factor 1 (IGF-1) plays an important role in neurogenesis and synaptogenesis and may be implicated in schizophrenia, although data so far have been inconclusive. The aim of our study was to compare levels of IGF-1 in drug-naïve patients with a first episode of schizophrenia and related disorders with matched healthy controls. Forty drug naïve first-episode patients with schizophrenia and related disorders and forty healthy subjects matched for age, gender, body mass index (BMI) and smoking status were enrolled in the study. Serum levels of IGF-1 for each sample were measured in duplicate by the enzyme-linked immunosorbent assay (ELISA) method using human IGF-1. The median IGF-1 levels were significantly higher in drug-naive patients with psychosis compared to healthy controls (109.66ng/ml vs. 86.96ng/ml, respectively p=0.039). Multiple regression analysis revealed that differences in serum IGF-1 values were independent of glucose metabolism (fasting glucose, fasting insulin, insulin resistance) and cortisol. These results show that IGF-1 may be implicated in the pathophysiology of psychosis but confirmation is needed from other studies.

anon11056724 · October 21, 2016, 5:06pm

I’m checking mine right now and they don’t seem to be elevated

Anon10 · October 21, 2016, 5:22pm

Does this have something to do with inflammation, I’m too lazy to search it on my own. If antiinflammatories are the way to go then you have a simply way to improve the situation for alot of us.

anon11056724 · October 21, 2016, 5:24pm

Already tried minocyclene. It had side effects and didn’t do jack ■■■■. I think this article is pertaining to the prodromal period anyway. Not very useful for those who already have the disease

y76 · October 22, 2016, 10:32am

French doctor André Gernez has proposed a structural hypothesis of schizophrenia whose pathogenic agent was Growth Factor Hormone which triggers underlying schizotaxia. He suggested to dry secretion of GF as a therapeutic proposal.

If you can read french. further information here : structural bis.pdf (2.0 MB)