Cognitive effectiveness of risperidone and olanzapine in first-episode schizophrenia

anon79999497 · October 21, 2016, 3:47pm

Conclusions: The effects of the two psychotroptic drugs on clinical symptoms and cognitive functions are almost equal. Comprehensive cognitive impairment is found in first-episode schizophrenia, and risperidone and olanzapine could partially improve the performance of cognitive function as well as clinical symptoms. The higher the dosage of risperidone is, the less improvement the patients has in the speed of process domain

ncbi.nlm.nih.gov

[Cognitive effectiveness of risperidone and olanzapine in first-episode schizophrenia].

J Zhao, Y Zhang, YY Chao, J Ma, YF Yang, JY Zhao, YH Du, WW Li, XQ Song and LX Lü, Zhonghua yi xue za zhi, Oct 2016 11

Objective: To study the impairments of cognitive function in first-episode schizophrenia and the potential effectiveness of risperidone and olanzapine monotherapy on first-episode schizophrenia.Methods:A total of 57 first-episode schizophrenia and 30 healthy controls were assessed at baseline, and patients were assessed again after 8-week antipsychotics therapy.Results:The positive and negative symptom scale (PANSS) reductive ratio between the two groups was similar. At baseline, the performance of schizophrenia patients was significant poor than healthy controls in the four domains of cognitive function (P<0.05); after 8-week's antipsychotics therapy, the performance of Trail Making Test (t=3.862,P<0.05) and Verbal Learning (t=-3.073,P<0.05) got significant improvements in patients with risperidone, while in group of patients with olanzapine, the performance of Trail Making Test (t=3.587,P<0.05) and working memory domain (t=-2.891,P<0.05) got significant improvements. Spearman correlation analyses suggested that dosage of risperidone was negatively correlated with the score-reducing rate of the performance of Trail Making Test of patients (r=-0.391,P=0.048).Conclusions:The effects of the two psychotroptic drugs on clinical symptoms and cognitive functions are almost equal. Comprehensive cognitive impairment is found in first-episode schizophrenia, and risperidone and olanzapine could partially improve the performance of cognitive function as well as clinical symptoms. The higher the dosage of risperidone is, the less improvement the patients has in the speed of process domain.

anon11056724 · October 21, 2016, 4:18pm

I’ve taken risperdal and i moved very sloooowly

NutsAboutU · October 21, 2016, 5:25pm

I’m currently on 2.5mg olanzapine and 4mg clopixol per day, i.e. extremely low dose medication, and I’m still below par cognitively for me. I’ve done hundreds of hours of emdr eye movements and other brain training and I expected to get a speed boost when I got down to very low dose meds. I’ve had Sz for the past 30 years, so maybe by brain has just acquired a set point of being sluggish over the years.

Anon10 · October 21, 2016, 5:30pm

Olanzapine is good for working memory, overall I was still quite foggy on it. Risperidone slowed my thoughts down to molasses, my thoughts were frozen so I couldn’t function.