Any news on glutamatergic drugs in the pipeline?

Any new news on Naben or evenamide. I really want to know if these types of drugs are doing good things for people like us.

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Does that help with negative symptoms …

I haven’t seen anything new. News about Evenamide has been sparse. There are more studies on naben because it’s widely available.

However, there was some news on Pomaglumetad, Denovo pharma liscenced it and is developing biomarkers for who might benefit. Apparently, atypical antipsychotics turn down expression of certain genes as well, so past medication history might be a factor, besides the patient’s genotype.

You might be aware, Pomaglumetad failed a phase 3 trial, but researchers noticed some people got a good benefit from it.

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I forget, have you already tried sarcosine? Because that is thought to help repair damage to the glutamate system. In stydies, it had a beneficial effect on cognition, depression, and flat affect.