I hope my logic is correct in that if your current meds are working you can simply pick which category they are in and later take those other meds.
For instance: Risperidone works for me, so I would take the meds in the CYP2D6 category.
I hope my logic is correct in that if your current meds are working you can simply pick which category they are in and later take those other meds.
For instance: Risperidone works for me, so I would take the meds in the CYP2D6 category.
I don’t think it’s that simple. No I really don’t think it’s that simple.
CYP1A2 fast metabolizer
CYP2C19
Slower metaboliser for some drugs
CYP2D610
CYP2D610 reduced metabolism
CYP3A5 non-expressor
This is common for Caucasians, but rare for African populations. As a CYP3A5 non-expressor you are unable to metabolize some common medications. This influences the synthesis of cholesterol, steroids and other lipids. The enzyme metabolizes drugs such as olanzapine, tacrolimus, nifedipine and cyclosporine as well as the steroid hormones testosterone, progesterone and androstenedione.
From https://geneticoncept.com/index.html
Aripiprazole (Abilify)
Preliminary Research: Fewer than 750 people studied
Sensitivity: HIGH
Metabolism: REDUCED
Asenapine (Saphris)
[Preliminary Research. More than 750 people with the condition were studied, but the findings still need to be confirmed by the scientific community in an independent study of similar size.]
Sensitivity: LOW
Metabolism: HIGH
Chlorpromazine (Thorazine)
Preliminary Research: Fewer than 750 people studied
Sensitivity: HIGH
Metabolism: REDUCED
Clozapine (Clozaril)
Preliminary Research: Fewer than 750 people studied
Sensitivity: LOW
Metabolism: HIGH
Clozapine-induced weight gain
[Preliminary Research. More than 750 people with the condition were studied, but the findings still need to be confirmed by the scientific community in an independent study of similar size.]
LOW
Haloperidol (Haldol)
Preliminary Research: Fewer than 750 people studied
Sensitivity: HIGH
Metabolism: REDUCED
Iloperidone (Fanapt)
Preliminary Research: Fewer than 750 people studied
Sensitivity: HIGH
Metabolism: REDUCED
Lurasidone (Latuda)
Preliminary Research: Fewer than 750 people studied
Sensitivity: AVERAGE
Metabolism: INTERMEDIATE
Olanzapine (Zyprexa)
Preliminary Research: Fewer than 750 people studied
Sensitivity: LOW
Metabolism: HIGH
Perphenazine (Trilafon)
Preliminary Research: Fewer than 750 people studied
Sensitivity: HIGH
Metabolism: REDUCED
Promazine (Sparine)
Preliminary Research: Fewer than 750 people studied
Sensitivity: LOW
Metabolism: HIGH
Quetiapine (Seroquel)
[Preliminary Research. More than 750 people with the condition were studied, but the findings still need to be confirmed by the scientific community in an independent study of similar size.]
Sensitivity: HIGH
Metabolism: REDUCED
Risperidone (Risperdal)
Preliminary Research: Fewer than 750 people studied
Sensitivity: HIGH
Metabolism: REDUCED
Thioridazine (Mellaril)
Preliminary Research: Fewer than 750 people studied
Sensitivity: HIGH
Metabolism: REDUCED
Ziprasidone (Geodon)
Preliminary Research: Fewer than 750 people studied
Sensitivity: AVERAGE
Metabolism: INTERMEDIATE
Amitriptyline (Elavil)
Preliminary Research: Fewer than 750 people studied
Sensitivity: HIGH
Metabolism: REDUCED
Bupropion
Preliminary Research: Fewer than 750 people studied
Sensitivity: TYPICAL
Metabolism: NORMAL
Citalopram (Celexa)
Preliminary Research: Fewer than 750 people studied
Sensitivity: AVERAGE
Metabolism: INTERMEDIATE
Clomipramine (Anafranil)
Preliminary Research: Fewer than 750 people studied
Sensitivity: HIGH
Metabolism: REDUCED
Desipramine (Norpramin)
Preliminary Research: Fewer than 750 people studied
Sensitivity: HIGH
Metabolism: REDUCED
Doxepin (Sinequan, Silenor, Prudoxin, Zonalon)
Preliminary Research: Fewer than 750 people studied
Sensitivity: HIGH
Metabolism: REDUCED
Escitalopram (Lexapro)
Preliminary Research: Fewer than 750 people studied
Sensitivity: AVERAGE
Metabolism: INTERMEDIATE
Fluoxetine (Prozac)
[Preliminary Research. More than 750 people with the condition were studied, but the findings still need to be confirmed by the scientific community in an independent study of similar size.]
Sensitivity: LOW
Metabolism: REDUCED
Imipramine (Tofranil)
Preliminary Research: Fewer than 750 people studied
Sensitivity: HIGH
Metabolism: REDUCED
Nefazodone (Serzone)
Preliminary Research: Fewer than 750 people studied
Sensitivity: AVERAGE
Metabolism: INTERMEDIATE
Nortriptyline (Aventyl,Pamelor)
Preliminary Research: Fewer than 750 people studied
Sensitivity: HIGH
Metabolism: REDUCED
Paroxetine (Paxil)
Preliminary Research: Fewer than 750 people studied
Sensitivity: HIGH
Metabolism: REDUCED
Sertraline (Zoloft)
Preliminary Research: Fewer than 750 people studied
Sensitivity: AVERAGE
Metabolism: INTERMEDIATE
Trazodone (Oleptro)
Preliminary Research: Fewer than 750 people studied
Sensitivity: AVERAGE
Metabolism: INTERMEDIATE
Venlafaxine (Effexor)
Preliminary Research: Fewer than 750 people studied
Sensitivity: HIGH
Metabolism: REDUCED
Alprazolam (Xanax)
Preliminary Research: Fewer than 750 people studied
Sensitivity: NORMAL TO LOW
Metabolism: NORMAL TO HIGH
Buspirone (BuSpar)
Preliminary Research: Fewer than 750 people studied
Sensitivity: AVERAGE
Metabolism: INTERMEDIATE
Diazepam (Valium)
Preliminary Research: Fewer than 750 people studied
Sensitivity: AVERAGE
Metabolism: INTERMEDIATE
Midazolam (Versed)
Preliminary Research: Fewer than 750 people studied
Sensitivity: AVERAGE
Metabolism: INTERMEDIATE
Phenobarbital triazolam (Halcion)
Preliminary Research: Fewer than 750 people studied
Sensitivity: NORMAL TO LOW
Metabolism: NORMAL TO HIGH
Zolpidem (Ambien)
Preliminary Research: Fewer than 750 people studied
Sensitivity: AVERAGE
Metabolism: INTERMEDIATE
I don’t get it o.O
Those are @firemonkey’s results from genetic testing. It looked at which gene variants he had governing metabolizing medications and told him how he could expect all those medications to affect him if he took them.
They are based on my genotypes which come from my 23andMe raw data.
Ohhh ok I see. I’m actually waiting to get my raw genetic data back from sequencing as well. Should get here in a few months, then I have to get it interpreted…but hopefully I’ll know that info for myself soon as well Personalized medicine is neat.
Ok, you got me. I’m cheap.
I will have to get the testing done, but once I’m in school it will be tough to get around to it. I’m preparing to go to school (and because it has lazy advisers, I won’t be able to get in without a fight.)